Friday, March 11, 2016

Update

After A LOT of blood at 24dpo, I had no bleeding for 3 days.  I thought (optimistically) that I might be done… and then I started spotting today.  My doctor said bedrest has not been shown to help, but that lots of rest was good.  So I have been resting when I can, but I think I was just not taking it easy enough.

I’m going to go off my prenatal vitamin, which includes fish oil, (I’ll replace it with a different prenatal) and eat a ton of red meat.  I hope it does not get any worse. 

My HCG at 24 dpo was 10693—exactly where it should be.*  Of course I continue to be nervous about the subchorionic hematoma, the developing pregnancy, and the apparent difficulty in finding a sac the other day.  Never a dull moment.

*Here are median HCG measurements from Betabase.  (http://www.betabase.info/)  My HCG continues to double right on schedule, compared to the median, and is even a little ahead. 

DPO
Median HCG Level
Doubling time
My HCG
12
49


13
85


14
129
2.63

15
191
2.25

16
284
2.20
519
17
409
2.14

18
588
2.07
1159
19
854
2.09

20
1222
2.08

21
1721
2.02

22
2389
1.95

23
3254
1.89

24
4283
1.79
10693


Tuesday, March 8, 2016

Already a threatened miscarriage (subchorionic hematoma)

I’m only “5 weeks pregnant” (ie the embryo was transferred less than 3 weeks ago) and of course I already have a threatened miscarriage.  I was sitting in my office today when all of the sudden I felt a gush between my legs.  I went into the bathroom and there was blood everywhere—it was reminiscent of unexpectedly getting my period when I was a teenager.  So that was not good.  (Fortunately I was wearing really thick tights and had an extra pair of underwear and a thick pad in my desk.)  I called my doctor’s office right away and they got me in for an ultrasound.  In the three hours between when the bleeding started and when I was at my doc’s office, I bled a lot.  Like filling a large pad every hour and larger than quarter sized clots in the toilet a lot.  

I went into the doc’s office and they confirmed it—I have a subchorionic hematoma.  A big one.  Right next to the (presumed*) sac.  He said that subchorionic hematomas are not uncommon, and that many women who have them will still go on to have a healthy pregnancy.  He said that until recently he would have put me on bed rest, but recent literature indicates it may not matter.  That’s not to say I’m going to be running a marathon anytime soon….  He said move slowly, walk softly, etc.  And if I want to do bed rest do bed rest.  But nothing strenuous.  No travel.

Okay, what’s a subchorionic hematoma?  Bleeding (hematoma) between the chorion (a membrane surrounding the embryo) and the uterine wall.  What causes it?  Who knows.

Subchorionic hematomas are vastly more common in IVF patients than the general population:


“[T]he frequency of SCH is significantly higher in the in vitro fertilization group (22.4%)”  (The study did not even INCLUDE women who did IVF)

The larger the hematoma the worse:  “A very large first-trimester hematoma is associated with a 46% risk of adverse pregnancy outcome”.

Even women whose pregnancies continue have more adverse outcomes: “In the case of prolongation of pregnancy, patients with SCH have a higher risk of maternal and neonatal complications of hypertension in pregnancy, preeclampsia, placental abruption, fetal growth retardation, fetal distress, and others”.

The study concluded that “pregnancy loss during the terms of 6 to 12 weeks in [SCH] patients was 4.64 times higher” than the non SCH patients.

For women with a “live fetus” about 10% with subchorionic hematomas miscarried.  The rates of miscarriage were higher (double) if the subchorionic hematoma was large.  The rates were higher (double) if the women were over 35.  And the rates were higher (double) if the bleeding was at less than 8 weeks gestation.

The overall spontaneous abortion rate was 9.3% (48 of 516 patients). The rate nearly doubled when the separation was large (18.8%) compared with small and moderate hematomas (7.7% and 9.2%, respectively). A large separation was found to be associated with an almost three-fold increase in risk of spontaneous abortion. The spontaneous abortion rate was approximately twice as high for women aged 35 years or older versus younger women (13.8% and 7.3%, respectively) and for women with bleeding at 8 weeks gestation or less compared with those with bleeding at greater than 8 weeks gestation (13.7% vs 5.9%).


Mine is large, I’m over 35, and I am at less than 8 weeks gestation.  Shit.  Shit.  Shit.

This article is even MORE of a bummer.  While it basically says nothing is proven, it goes through all of the bad shit that can happen from a SCH (miscarriage, placental abruption, etc):


This article suggests that there may be a benefit to bed rest:


It also reports that length of bleeding did not matter.

UGH.  Some of my long-time readers are like, “heeyyy, didn’t you have this before?”  I’m surprised you remembered!  Yes, sortof but not really.  With my son I had some kind of internal bleed (that they never fully diagnosed, even when I was released to the high-risk OB):


But I never had any external bleeding, so it was less scary than this.

I also talked to my doctor about my strange and very severe 12-hour morning sickness.  He was like, “yea, probably not.  Sounds like a bug.”  Son of a bitch!  I did NOT want to get sick during my neural tube closure window.  Also, he told me to go off of my aspirin and Medrol right away.  So that solves the question of how long I’ll be on Medrol.

So what to do?  Rest and hope it goes away.  The bleeding seems to have stopped (at least externally) for now.  No surprise—I have been doing a 12-hour kegel. 

*The sac is so tiny at this point that they were not 100% sure it was even there—they identified something they thought was the sac.  It was measuring at 5w0d, even though I’m 5w3d.  I don’t know how much I can read into that when they were not even sure what they were looking at.  I think they should have been able to more easily identify the sac at this point.  This is all just really bad.

If things were going the way they should have been going, my HCG should be hovering around 10,000.  I know that 5w3d is early for a heartbeat… but it’s not that early.  This article seems to suggest that they should have easily seen a sac, yolk, and maybe even heartbeat:

When the level of HCG reached 1000 mIU/ml by using the first International Reference Preparation, a gestational sac was seen sonographically in each patient. When the HCG level reached 7200 mIU/ml, a yolk sac was seen in every patient. Ten of 22 patients with HCG between 1000 and 7200 mIU/ml had a visible yolk sac. Every patient with an HCG level greater than 10,800 mIU/ml had a visible embryo with a heartbeat. A discriminatory level of 32 days was found for the presence of a gestational sac. A yolk sac was first seen in every patient between 36 and 40 days. Every patient with accurate dates greater than 40 days had an embryo with a heartbeat identified. When correlating sac size with structures within the sac, a yolk sac was first seen in a gestational sac between 6 and 9 mm and a heartbeat seen in every patient with a 9-mm or greater gestational sac diameter.


Dammit!

Sunday, March 6, 2016

Careful what you wish for

As I complained just a few days ago, I still don’t feel pregnant.  No sore breasts, no morning sickness.  Last night I was reading about morning sickness, and read that it tends not to affect people until they are 6 weeks pregnant (from LMP). I was exactly 5 weeks yesterday, so I decided to stop worrying about it and just enjoy the fact that I feel good.

Oh, the irony.  I woke up last night feeling AWFUL—nauseated, upset stomach, etc.  I was up a fair bit of the night and still felt terrible in the morning.  My husband went out and got me crackers and ginger ale, and I spent the morning in bed.  (My son collected all of his doctor’s things by my bedside—and a toy saw, in case I needed surgery—to take care of me.)  I have not actually vomited yet, although I suspect I would feel better if I did.

I started to feel better in the late morning.  Maybe the ginger ale and crackers helped.  This study suggests that ginger really does help, without risk to the developing baby:


Blech.  I know I should be happy that this is an indication that my HCG and progesterone are rising and that my pregnancy is progressing.  And I mostly am.  But being sick sucks.

Thursday, March 3, 2016

Medrol during IVF

Prednisone, methylprednisolone (Medrol) and prednisolone all cross the placenta, but are “inactivated” so that most of the steroid does not reach the developing baby. 


(“Betamethasone and dexamethasone cross the placenta readily. Up to ninety percent of prednisolone and methylprednisolone is inactivated by the placenta.”)

So they are the preferred steroid for treatment during pregnancy.

As already discussed, my doctor originally wanted me to use dexamethasone, but settled on Medrol. 


Nevertheless, you’d rather NOT be on a steroid during pregnancy.  This article reports on a baby whose mom had high doses of Medrol through her pregnancy:


The baby had adrenal suppression (its adrenal glands were suppressed from steroid use).  Yuck.

There is also some suggestion that corticosteroids increase the risk of an oral cleft when used in the first trimester:


So you definitely do not want to be on a steroid any longer than necessary.

As far as I can tell, most clinics do not have their patients on Medrol much past embryo transfer.  Many clinics have patients start Medrol (16 mg tablet) on the night of their egg retrieval (to slightly suppress the immune system and prevent any inflammation) for 4 days:


Other clinics keep patients on Medrol through the 6th week of gestation (maybe?):


Clinics will keep patients on prednisone (or prednisolone) through the first trimester, though:


I’m not sure how long my doctor wants me on Medrol (I’m not sure HE knows), but I’m going to do my best to get off of it asap.  In other words, I was desperate trying to get on a steroid, and now I’m desperately trying to get off of it.

Wednesday, March 2, 2016

Neural tube closure

Pregnancy via IVF has a number of hurdles.  Have a normally shaped uterus, have good blood circulation, don’t have any fertility-limiting illnesses, respond to the drugs, get enough eggs, have the eggs be mature, get some sperm, have the sperm not suck, get the sperm to fertilize the eggs, get the embryos to grow and hopefully reach blastocyst stage, biopsy them and have them be normal, have them survive the thaw, grow a good enough lining [*], get the embryo to implant [*], have the embryo implant somewhere that it could actually grow (ie not the damn fallopian tube) [*], have the embryo grow (ie no blighted ovum) [*], have the “chromosomally normal” embryo be genetically normal as well [*]… and that just gets you through the first trimester.  Then you’ve got to worry about infections, growth restriction, trauma, cord issues, food poisoning, mosquito bites, plagues, super volcanos, etc.  It’s amazing anyone is walking around on earth at all.

We’ve stumbled on a number of these necessities.  (See stars above.)  Even if I do manage to get pregnant (which I have done most cycles), I have a really hard time getting those pregnancies off of the ground, and I appear to have some non-chromosomal genetic issues.  The most devastating of which, of course, was my anencephaly pregnancy.  

I’m already doing everything I can to avoid a repeat of an anencephaly pregnancy.  (5mg folic acid, inositol supplementation.)  But, even if I am lucky enough to get to implantation and what appears to be normal growth, I am going to be on pins and needles until an ultrasound tech tells me sometime around 12 weeks during a level 2 ultrasound that we’re in the clear and that our baby does not have some kind of catastrophic disorder that is incompatible with life.

The neural tube closes between 3-4 weeks after conception, or when a woman is “six weeks” pregnant.  (So that’s 21-28dpo, or 16-23dp6dt for me.)  I have marked that critical week on my calendar.  If I so much as hear someone sneeze around that time, I’m going to put on one of those surgical facemasks.  I’m going to take a nap every day.  I’m going to avoid sugar and caffeine (not that I ever have caffeine).  I’m going to avoid stress and travel and exertion and baths and long showers.  I’m going to only eat organic fruit and drink purified water blessed by mountain-dwelling monks while chanting “neural tube close, neural tube close.” 

Anything else I should be thinking about?

Oh, and I should mention—second HCG was good (1159 at 18dpo—almost exactly doubled in two days, as it should).  Next stop, neural tube closure!

Tuesday, March 1, 2016

Sex during an IVF cycle (and especially before transfer)—just do it!

I’ve mentioned this before. Allegedly sex before transfer can increase pregnancy rates:


And some scientists suggest that more sex as a general matter may actually increase your chances of getting pregnant, although the reasons why are unclear:


It’s good to know that sex actually has some potential procreative value even after you’ve started down the IVF path!  Of course, if you’re on suppositories you will have started them before the transfer.  Nothing gets a man in the mood like some warm creamy progesterone in the who-ha, amiright???  (Unless you’re doing the butt-shots, which are obviously a whole other kind of aphrodisiac, if you’re into that kind of thing.)

Monday, February 29, 2016

Very strongly pregnant

Okay, ummmm, it worked.  It REALLY worked.  I got the call from my doc’s office this afternoon.  He said I was “very strongly pregnant.”  My HCG at 16dpo was 519.  519.  That’s high.  Higher than my son was, which, as I said just yesterday, I would be thrilled to have.  Much higher than the median self-reported for continuing to heartbeat (which is 282).  Based on studies on HCG measurements, it’s >95% likely for a continuing pregnancy.  That’s like TWINS high.  (Okay, okay, not really.  Let’s not get hysterical here!)  And I thought my crappy little thawed day 6 was going to be a dud!  I threw a multi-day tantrum last week!  Goes to show you never can tell.

Of course, we know that my diagnosis is “unexplained, likely high number of genetically abnormal embryos.”  Yuck.  If that’s true, this could be a ticking time bomb.  For a normal person, an HCG of 519 at 16dpo with a chromosomally normal embryo would be a fantastic sign.  For me… well, we will just take it one day at a time.  But, it implanted.  It stuck.  And it’s still going (or at least was).  And that number is high enough that I am HOPING it’s not ectopic.  I have another blood test on Wednesday to confirm that HCG is doubling.  That should rule out an early miscarriage or ectopic.  Then we just have to make it to neural tube closure.  And heartbeat….  But today, things are as good as they could be.