Friday, April 14, 2017

Antinuclear antibodies (ANA) / Anti-thyroid antibodies / antiphospholipid antibodies (APA) / antiovarian antibodies (AOA)

Here’s post 1 of 2 on some of the more “pseudo-science” infertility issues: antinuclear antibodies (ANA), anti-thyroid antibodies / antiphospholipid antibodies (APA), and antiovarian antibodies (AOA).

This article suggests that in a small study of women with antithyroid autoimmunity, “pregnancy rate was 33.3% (8/24) among women treated with prednisone [starting 4 weeks before IUI] compared with 8.4% (2/24) among women who received placebo …. In the antibody-negative group, the pregnancy rate was 8.0% (4/50). Among the pregnancies, the miscarriage rate was 70% (7/10) versus 75% (3/4) for women with or without antithyroid antibodies, respectively (P = NS); the miscarriage rate was 75% (6/8) for women treated with prednisone versus 50% (1/2) for women taking placebo (P = 0.49). No adverse effects were reported.”  In other words, prednisone works for women with antithyroid autoimmunity.  But yikes, that’s a high miscarriage rate!  

This article suggests “Anti-nuclear antibodies (ANA) are suspected of having relevance to adverse reproductive events. . . . These observations suggest that ANA could exert a detrimental effect on IVF/ICSI outcome that might not be titre-dependent, and [prednisone plus low-dose aspirin] adjuvant treatment could be useful for ANA + patients.”

This article suggest “Anti-thyroid antibodies (ATA), even if not associated with thyroid dysfunction, are suspected to cause poorer outcome of in vitro fertilization (IVF). . . . euthyroid ATA+ patients undergoing IVF could have better outcome if given [levothyroxine, acetylsalicylic acid, and prednisolone] as adjuvant treatment”:

This article suggests that pregnancy rates are very low in non-treated ANA-positive women (0%) and were higher when women were treated with prednisone:

Here’s another one that says the same thing:

Here are some other links:

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